28 Head and Neck Cancer Studies Reviews

Topic outline

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  Course Introduction

  • Audio Message from Bhupesh Parashar, MD DrPH File 276.8KB Audio file (MP3) Uploaded 6/04/21, 04:51

      
    

                Bhupesh Parashar

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  Major Head and Neck Studies Reviews

  Below is the list of 28 audio summaries and articles in PDF format of major head and neck cancer studies.

  • Larynx Concurrent ChemoRT vs Sequential vs RT alone

    Concurrent Chemotherapy and Radiotherapy for Organ Preservation in Advanced Laryngeal Cancer (Forastiere et al. 2003)
    

  • Larynx Preserve RTOG 91-11 (Audio) File 1.7MB Audio file (MP3) Uploaded 31/03/21, 00:26
  • RTOG 91-11 2003 (PDF) File
  • ChemoRT vs RT for Early Stage Nasopharynx

    Concurrent Chemoradiotherapy vs Radiotherapy Alone in Stage II Nasopharyngeal Carcinoma: Phase III Randomized Trial (Chen et al. 2011)
    

  • Stage 2 NP, Chinese, 2011, JNCI (Audio) File 2.1MB Audio file (MP3) Modified 5/04/21, 12:36
  • Stage 2 NP-Chinese 2011 (PDF) File
  • Postop RT vs Postop ChemoRT

    Postoperative Concurrent Radiotherapy and Chemotherapy for High-Risk Squamous-Cell Carcinoma of the Head and Neck (Cooper et al. 2004)
    

  • RTOG 95-01 - Postop High Risk, 2004 (Audio) File 4.6MB Audio file (M4A) Uploaded 6/04/21, 16:25
  • RTOG95-01 High Risk Post-op (PDF) File
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  • Postoperative Irradiation with or without Concomitant Chemotherapy for Locally Advanced Head and Neck Cancer (Bernier et al. 2004)

  • EORTC 22931, Postop High Hisk, 2004 (Audio) File 5.6MB Audio file (M4A) Modified 11/12/20, 09:28
  • EORTC High Risk Postop (PDF) File
  • RT vs ChemoRT Oropharynx

    Final Results of the 94-01 French Head and Neck Oncology and Radiotherapy Group Randomized Trial Comparing Radiotherapy Alone With Concomitant Radiochemotherapy in Advanced-Stage Oropharynx Carcinoma (Denis et al. 2004)
    

  • Gortec trial 94-01, 2004, JCO (Audio) File 3.6MB Audio file (M4A) Modified 11/12/20, 09:28
  • Gortec 94-01 JCO 2004 (PDF) File
  • Induction Chemo followed by CRT vs CRT

    Induction chemotherapy followed by concurrent chemoradiotherapy (sequential chemoradiotherapy) versus concurrent chemoradiotherapy alone in locally advanced head and neck cancer (PARADIGM): a randomised phase 3 trial (Haddad et al. 2013)
    

  • PARADIGM Trial, Haddad et al, 2013, Lancet Onc (Audio) File 4.3MB Audio file (M4A) Modified 11/12/20, 09:28
  • Paradigm trial 2013 (PDF) File
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  • A randomized phase III trial comparing induction chemotherapy followed by chemoradiotherapy versus chemoradiotherapy alone as treatment of unresectable head and neck cancer (Hitt et al. 2013)

  • Spanish Induction Chemo Trial- Hitt et al 2014 (Audio) File 5.9MB Audio file (M4A) Modified 11/12/20, 09:29
  • Hitt-Induction Chemo vs. Chemoradio Head and Neck (PDF) File
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  • Phase III Randomized Trial of Induction Chemotherapy in Patients With N2 or N3 Locally Advanced Head and Neck Cancer (Cohen et al. 2014) 

  • DECIDE Trial - Induction Chemo vs Crt 2014 (Audio) File 5.8MB Audio file (M4A) Uploaded 11/12/20, 09:16
  • DECIDE Trial-Induction Chemo 2014 (PDF) File
  • Quiz - Based on Decide and Paradigm Trial
  • Parsport Trial: IMRT vs Conventional - Parotid Sparing

    Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial (Nutting et al. 2011)
    

  • PARSPORT Trial_IMRT vs Conventional RT 2011 (Audio) File 4.4MB Audio file (M4A) Modified 11/12/20, 09:29
  • PARSPORT trial 2011 (PDF) File
  • 6 Fractions/wk vs 5 Fractions/wk

    Five compared with six fractions per week of conventional radiotherapy of squamous-cell carcinoma of head and neck: DAHANCA 6&7 randomised controlled trial (Overgaard et al. 2003)
    

  • Dahanca Trial 2003 (Audio) File 5.9MB Audio file (M4A) Modified 11/12/20, 09:29
  • Dahanca Trial 2003 (PDF) File
  • Glottic Fractionation Study

    Radiotherapy for Early Glottic Carcinoma (T1N0M0): Results of Prospective Randomized Study of Radiation Fraction Size and Overall Treatment Time (Yamazaki et al. 2006)
    

  • Glottis 2Gy vs 2.25 Gy 2006 Yamasaki et al (Audio) File 4.4MB Audio file (M4A) Modified 11/12/20, 09:29
  • Yamasaki Glottic 2006 (PDF) File
  • RT vs RT + Cetuximab

    Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival (Bonner et al. 2010)
    

  • Bonner Trial, Lancet Oncology 2010 (Audio) File 3.5MB Audio file (M4A) Modified 11/12/20, 09:30
  • Bonner trial update 2010 (PDF) File
  • Nasopharynx - RT vs ChemoRT- Al Sarraf

    Chemoradiotherapy Versus Radiotherapy in Patients With Advanced Nasopharyngeal Cancer: Phase III Randomized Intergroup Study 0099 (Al-Sarraf et al. 1998)
    

  • Nasopharynx Al-Sarraf 1998 (Audio) File 3.8MB Audio file (M4A) Modified 11/12/20, 09:31
  • Al Sarraf -Nasopharynx (PDF) File
  • Radiation vs. Chemoradiation vs. Split-Course Chemoradiation

    An Intergroup Phase III Comparison of Standard Radiation Therapy and Two Schedules of Concurrent Chemoradiotherapy in Patients With Unresectable Squamous Cell Head and Neck Cancer (Adelstein et al. 2003)
    

  • Adelstein study 2003, JCO, phase 3 (Audio) File 4.2MB Audio file (M4A) Uploaded 11/12/20, 07:29
  • Adelstein 2003 JCO (PDF) File
  • Hyper-Fractionation in Early Stage

    Randomized Trial of Hyperfractionation versus Conventional Fractionation in T2 Squamous Cell Carcinoma of the Vocal Cord (RTOG 9512) (Trotti et al. 2014)
    

  • RTOG 95-12 Trotti 2014 (Audio) File 3.5MB Audio file (M4A) Uploaded 11/12/20, 07:36
  • RTOG 95-12 trotti (PDF) File
  • Elective vs. Salvage Dissection

    Elective versus Therapeutic Neck Dissection in Node-Negative Oral Cancer (D’Cruz et al. 2015)
    

  • D’Cruz et al. NEJM 2015 (Audio) File 4MB Audio file (M4A) Uploaded 11/12/20, 07:40
  • D'Cruz 2015 NEJM (PDF) File
  • RT + Cisp vs RT + Cetuximab HPV + OP

    Radiotherapy plus cetuximab or cisplatin for human papillomavirus (HPV)-positive oropharyngeal cancer: a randomized, multicenter, non-inferiority clinical trial (Gillison et al. 2019)
    

  • RTOG 1016 RT plus Cis vs RT+Cetux 2019 (Audio) File 6.1MB Audio file (M4A) Uploaded 11/12/20, 07:46
  • Cetuximab vs Cisplatin RTOG 1016 (PDF) File
  • RT + Cisp vs RT + Cisp + Cetuximab

    Randomized Phase III Trial of Concurrent Accelerated Radiation Plus Cisplatin With or Without Cetuximab for Stage III to IV Head and Neck Carcinoma: RTOG 0522 (Ang et al. 2014)
    

  • RTOG 0522 Ang 2014 JCO (Audio) File 6.7MB Audio file (M4A) Uploaded 11/12/20, 07:57
  • RTOG 0522 RT Cetux+Cisp v Cisp (PDF) File
  • ChemoRT (2 Types) vs Accelerated RT in HN cancers

    Concomitant chemoradiotherapy versus acceleration of radiotherapy with or without concomitant chemotherapy in locally advanced head and neck carcinoma (GORTEC 99-02): an open-label phase 3 randomised trial (Bourhis et al. 2012)
    

  • GORTEC 99-02 French 2012 Lancet Onc (Audio) File 8.4MB Audio file (M4A) Uploaded 11/12/20, 08:13
  • GORTEC 99-02 2012 (PDF) File
  • IMRT vs Conventional - Parotid Sparing

    Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial (Nutting et al. 2011)
    

  • PARSPORT Trial - IMRT vs Conventional RT 2011 (Audio) File 4.4MB Audio file (M4A) Uploaded 11/12/20, 08:17
  • PARSPORT Trial 2011 (PDF) File
  • RTOG 0129 HPV Positive vs Negative Prognosis

    Human Papillomavirus and Survival of Patients with Oropharyngeal Cancer (Ang et al. 2010)
    

  • RTOG 0129 HPV Study KKang 2010 NEJM (Audio) File 7.5MB Audio file (M4A) Uploaded 11/12/20, 08:23
  • HPV NEJM Ang (PDF) File
  • Quiz - based on KKAng RTOG 0129 study
  • Accelerated Hypofrac in Early Stage OP

    Multi-institutional Trial of Accelerated Hypofractionated IntensityModulated Radiation Therapy for Early Stage Oropharyngeal Cancer (RTOG 00-22) (Eisbruch et al. 2010)
    

  • RTOG 0022 Red Journal 2010 Phase 1-2 (Audio) File 4.3MB Audio file (M4A) Uploaded 11/12/20, 08:31
  • RTOG 0022-2010 (PDF) File
  • Salvage Surgery plus ReRTchemo vs Surgery alone

    Randomized Trial of Postoperative Reirradiation Combined With Chemotherapy After Salvage Surgery Compared With Salvage Surgery Alone in Head and Neck Carcinoma (Janot et al. 2008)
    

  • French ReRT plus Chemo vs Observation 2008JCO (Audio) File 5MB Audio file (M4A) Uploaded 11/12/20, 08:44
  • French ReRT+Chemo Postoperative (PDF) File
  • Hyperfx vs Convfx OP

    Hyperfractionation versus conventional fractionation in oropharyngeal carcinoma: final analysis of a randomized trial of the EORTC cooperative group of radiotherapy (Horiot et al. 1992)
    

  • EORTC 22791 Hyperfx vs CF Oropharynx 1992 (Audio) File 3.7MB Audio file (M4A) Uploaded 11/12/20, 08:49
  • EORTC 22791 1992 (PDF) File
  • 6Fx per Week vs 5 Fractions per Week IAEA Study 2010

    Five versus six fractions of radiotherapy per week for squamous-cell carcinoma of the head and neck (IAEA-ACC study): a randomised, multicentre trial (Overgaard et al. 2010)
    

  • IAEA 6 Fraction vs 5 Fx RT (Audio) File 4.9MB Audio file (M4A) Uploaded 11/12/20, 08:54
  • IAEA Study 6fx vs 5 Fx 2010 (PDF) File
  • Preop vs Postop RT in HN cancers

    Randomized Study of Preoperative versus Postoperative Radiation Therapy in Advanced Head and Neck Carcinoma: Long-Term follow-up of RTOG study 73-03 (Tupchong et al. 1990)
    

  • RTOG 73-03 Pre vs Postop (Audio) File 3.5MB Audio file (M4A) Uploaded 5/04/21, 16:36
  • RTOG 70-03 (PDF) File
  • 4 Types of Fractionation compared in Advanced HN

    Final Results of Local-Regional Control and Late Toxicity of RTOG 90-03; A Randomized Trial of Altered Fractionation Radiation for Locally Advanced Head And Neck Cancer (Beitler et al. 2014)
    

  • Kk Fu Study RTOG 9003 (Audio) File 3.5MB Audio file (MP3) Uploaded 5/04/21, 15:30
  • RTOG 90-03 (PDF) File
  • Induction TPF vs PF

    Long term results of TAX324, a randomized phase III trial of sequential therapy with TPF versus PF in locally advanced squamous cell cancer of the head and neck (Lorch et al. 2011)

  • Induction TPF vs PF (Audio) File 4.1MB Audio file (M4A) Uploaded 6/04/21, 03:09
  • TAX 324 (PDF) File
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