Topic outline
Course Introduction
Bhupesh Parashar
Major Head and Neck Studies Reviews
Below is the list of 28 audio summaries and articles in PDF format of major head and neck cancer studies.
Larynx Concurrent ChemoRT vs Sequential vs RT alone
Concurrent Chemotherapy and Radiotherapy for Organ Preservation in Advanced Laryngeal Cancer (Forastiere et al. 2003)
ChemoRT vs RT for Early Stage Nasopharynx
Concurrent Chemoradiotherapy vs Radiotherapy Alone in Stage II Nasopharyngeal Carcinoma: Phase III Randomized Trial (Chen et al. 2011)
Postop RT vs Postop ChemoRT
Postoperative Concurrent Radiotherapy and Chemotherapy for High-Risk Squamous-Cell Carcinoma of the Head and Neck (Cooper et al. 2004)
-----------------
Postoperative Irradiation with or without Concomitant Chemotherapy for Locally Advanced Head and Neck Cancer (Bernier et al. 2004)
RT vs ChemoRT Oropharynx
Final Results of the 94-01 French Head and Neck Oncology and Radiotherapy Group Randomized Trial Comparing Radiotherapy Alone With Concomitant Radiochemotherapy in Advanced-Stage Oropharynx Carcinoma (Denis et al. 2004)
Induction Chemo followed by CRT vs CRT
Induction chemotherapy followed by concurrent chemoradiotherapy (sequential chemoradiotherapy) versus concurrent chemoradiotherapy alone in locally advanced head and neck cancer (PARADIGM): a randomised phase 3 trial (Haddad et al. 2013)
-----------------
A randomized phase III trial comparing induction chemotherapy followed by chemoradiotherapy versus chemoradiotherapy alone as treatment of unresectable head and neck cancer (Hitt et al. 2013)
-----------------
Phase III Randomized Trial of Induction Chemotherapy in Patients With N2 or N3 Locally Advanced Head and Neck Cancer (Cohen et al. 2014)
Parsport Trial: IMRT vs Conventional - Parotid Sparing
Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial (Nutting et al. 2011)
6 Fractions/wk vs 5 Fractions/wk
Five compared with six fractions per week of conventional radiotherapy of squamous-cell carcinoma of head and neck: DAHANCA 6&7 randomised controlled trial (Overgaard et al. 2003)
Glottic Fractionation Study
Radiotherapy for Early Glottic Carcinoma (T1N0M0): Results of Prospective Randomized Study of Radiation Fraction Size and Overall Treatment Time (Yamazaki et al. 2006)
RT vs RT + Cetuximab
Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival (Bonner et al. 2010)
Nasopharynx - RT vs ChemoRT- Al Sarraf
Chemoradiotherapy Versus Radiotherapy in Patients With Advanced Nasopharyngeal Cancer: Phase III Randomized Intergroup Study 0099 (Al-Sarraf et al. 1998)
Radiation vs. Chemoradiation vs. Split-Course Chemoradiation
An Intergroup Phase III Comparison of Standard Radiation Therapy and Two Schedules of Concurrent Chemoradiotherapy in Patients With Unresectable Squamous Cell Head and Neck Cancer (Adelstein et al. 2003)
Hyper-Fractionation in Early Stage
Randomized Trial of Hyperfractionation versus Conventional Fractionation in T2 Squamous Cell Carcinoma of the Vocal Cord (RTOG 9512) (Trotti et al. 2014)
Elective vs. Salvage Dissection
Elective versus Therapeutic Neck Dissection in Node-Negative Oral Cancer (D’Cruz et al. 2015)
RT + Cisp vs RT + Cetuximab HPV + OP
Radiotherapy plus cetuximab or cisplatin for human papillomavirus (HPV)-positive oropharyngeal cancer: a randomized, multicenter, non-inferiority clinical trial (Gillison et al. 2019)
RT + Cisp vs RT + Cisp + Cetuximab
Randomized Phase III Trial of Concurrent Accelerated Radiation Plus Cisplatin With or Without Cetuximab for Stage III to IV Head and Neck Carcinoma: RTOG 0522 (Ang et al. 2014)
ChemoRT (2 Types) vs Accelerated RT in HN cancers
Concomitant chemoradiotherapy versus acceleration of radiotherapy with or without concomitant chemotherapy in locally advanced head and neck carcinoma (GORTEC 99-02): an open-label phase 3 randomised trial (Bourhis et al. 2012)
IMRT vs Conventional - Parotid Sparing
Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial (Nutting et al. 2011)
RTOG 0129 HPV Positive vs Negative Prognosis
Human Papillomavirus and Survival of Patients with Oropharyngeal Cancer (Ang et al. 2010)
Accelerated Hypofrac in Early Stage OP
Multi-institutional Trial of Accelerated Hypofractionated IntensityModulated Radiation Therapy for Early Stage Oropharyngeal Cancer (RTOG 00-22) (Eisbruch et al. 2010)
Salvage Surgery plus ReRTchemo vs Surgery alone
Randomized Trial of Postoperative Reirradiation Combined With Chemotherapy After Salvage Surgery Compared With Salvage Surgery Alone in Head and Neck Carcinoma (Janot et al. 2008)
Hyperfx vs Convfx OP
Hyperfractionation versus conventional fractionation in oropharyngeal carcinoma: final analysis of a randomized trial of the EORTC cooperative group of radiotherapy (Horiot et al. 1992)
6Fx per Week vs 5 Fractions per Week IAEA Study 2010
Five versus six fractions of radiotherapy per week for squamous-cell carcinoma of the head and neck (IAEA-ACC study): a randomised, multicentre trial (Overgaard et al. 2010)
Preop vs Postop RT in HN cancers
Randomized Study of Preoperative versus Postoperative Radiation Therapy in Advanced Head and Neck Carcinoma: Long-Term follow-up of RTOG study 73-03 (Tupchong et al. 1990)
4 Types of Fractionation compared in Advanced HN
Final Results of Local-Regional Control and Late Toxicity of RTOG 90-03; A Randomized Trial of Altered Fractionation Radiation for Locally Advanced Head And Neck Cancer (Beitler et al. 2014)
Induction TPF vs PF
Long term results of TAX324, a randomized phase III trial of sequential therapy with TPF versus PF in locally advanced squamous cell cancer of the head and neck (Lorch et al. 2011)
Feedback and Comments
This site is currently in active development. We are looking forward to reading your feedback and ideas.
Please note: You have to be logged in to be able to provide your feedback. If you do not have an account, please sign up first.